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    ملخص الابدومولوجي

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    A B D

    عدد الرسائل: 36
    تاريخ التسجيل: 22/06/2008

    ملخص الابدومولوجي

    مُساهمة من طرف A B D في الأربعاء فبراير 04, 2009 2:32 pm

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    Epidemiology:

    Is the study of frequency, distribution & determinants of health & health related events occurring in community and application of this knowledge to prevent diseases, promot health & prolong life.



    Measurement of mortality:

    Case fatality rates = Total no of deaths(disease) / Total no of cases(same disease)



    Measurement of morbidity:

    Attack rate: Is an incidence rate when population is exposed to risk for a limited period of time( during an epidemic)

    Secondary attack rate:

    Number of exposed persons developing disease within the range of the incubation period following exposure to a primary case.



    Measurement of fertility (Natality):

    a. Crude birth rate (CBR) = (no. of live birth in yr / mid yr population) X 1000.

    b. General fertility rate (GFR) = (no. of live birth in yr / no. of women in age (15-49yr) ) X 1000.

    c. Total fertility rate (TFR) = average no of children a women would have during her reproductive yrs.

    d. Net reproduction rate (NRR) = no of daughters born to women.







    Cross-sectional / prevalence study:

    simplest, observational, based on single observation / examination of cross-section of population, at one point of time, more useful for chronic diseases.



    Longitudinal studies / Incidence:

    observation are repeated in same population over a prolonged period of time by follow-up examinations.



    Secular trends:

    The long-term-time trend of disease occurrence. There are changes in the incidence or prevalence of a disease that occur over long periods of time.



    Epidemics:

    are increase in incidence above the expected in a defined geographic area within a defined time period. Used in respect of infectious diseases. / تعريف شرشور Sudden increase of causes of a particular disease (high expectation).



    Personal characteristics:

    Host factors(age, gender, sex, lifestyle, marital status).



    Differences in personal characteristics may contribute to disease occurrence in the following ways:

    1. Determining degree of exposure

    2. differences in susceptibility

    3. likelihood of specific immunity.





    Features of case control method:

    a. Exposure and outcome occurred before the start of the study.

    b. Study proceeds backwards from effect to cause.

    c. Uses a control to support the result.



    Basic steps of case control study:

    1. Selection of cases and controls.

    2. Matching.

    3. Measurement of exposure.

    4. Analysis.

    5. Interpretation of results.



    Matching:

    The process by which we select controls in such a way that they are similar to cases with regard to certain pertinent selected variables which influence the outcome of disease, if not adequately matched for comparability could distort the results.



    Confounding factor:

    Defined as one which is associated both with exposure and disease and distributed equally in study and control groups. E.g. smoking, drinking alcohol.









    A B D

    عدد الرسائل: 36
    تاريخ التسجيل: 22/06/2008

    رد: ملخص الابدومولوجي

    مُساهمة من طرف A B D في الأربعاء فبراير 04, 2009 2:36 pm

    Page 21: A case control study of smoking and lung cancer:




    Cases (with lung cancer)

    Controls ( without lung cancer )

    Total

    smoker


    a

    b

    a + b



    Non-smokers

    c

    d

    c + d

    Total


    a + c

    b + d

    a + b + c + d




    Exposure rates:

    a. Cases = a / (a + c) ---- percent %

    b. Controls = b / (b + d) ---- percent %



    Odds Ratio = ad / bc



    Odds ratio: Is a measure of three strength of the associate between risk factor and outcome Odds ratio is closely related relative risk



    Advantages of case-control studies:

    1. Easy to carry out.

    2. Rapid and inexpensive.

    3. Require few subjects.

    4. No risk to subjects.

    5. Risk factors can be identified.





    Disadvantages of case-control studies:

    1. Problems of bias.

    2. Difficult selection of an appropriate control group.

    3. We cannot measure incidence.

    4. Don’t distinguish between causes and associated factors.

    5. Cannot evaluate treatment or prevention.



    Names of cohort study:

    *Prospective study.

    *Longitudinal study.

    *Incidence study.

    *Forward-looking study.



    · case control study: effect to causes.

    cohort study: causes to effect.



    · case control study: expoures and disease have already occurred when start study.

    cohort study: expoure has occurred but diasese not.



    Types of cohort studies:

    *Prospective cohort studies.

    *Retrospective cohort studies.

    *combination of retrospective& prospective cohort studies.



    Elements of a cohort study:

    *Selection of study subjects. *Obtaining data on exposure.

    *Selection of comparison groups.

    *Follow-up. *Analysis (to find the risk).



    Estimation of risk:

    A. Relative risk: is the ratio of the incidence of the disease (or death) among exposed and the incidence among non-exposed.

    RR= Incidence of disease (or death) among exposed / Incidence of disease (or death) among non-exposed.



    Estimation of RR is important in aetiological enquiries. It is a direct measures (or index) of the “strength” of the association between suspected cases and effects.



    The larger the RR, the greater is the “strength” of the association between suspected factor and disease.



    B. Attributable risk:

    ( Incidence of dis. rate among exposed – Incidence of dis. rate among non-exposed / Incidence rate among exposed ) X 100 (percent %)



    مراجعة الجدول ص 35 Table no.7

    A B D

    عدد الرسائل: 36
    تاريخ التسجيل: 22/06/2008

    رد: ملخص الابدومولوجي

    مُساهمة من طرف A B D في الأربعاء فبراير 04, 2009 2:38 pm

    Advantages of cohort studies:

    1. Incidence can be calculated.

    2. Outcomes related to exposure can be studied simultaneously.

    3. Provide a direct estimate of relative risk.

    4. Dose-response ratios can also be calculated.

    5. Since comparison groups are formed before disease develops.





    Disadvantages of cohort studies:

    1. Involve large number of people.

    2. Takes long time to complete the study.

    3. Problems such as loss of experienced staff

    4. Loss to follow-up.

    5. Expensive.



    Table no.11



    Case Control Study

    Cohort Study


    1

    Proceeds from “effect to cause”

    Proceeds from “cause to effects”

    2

    Starts with the disease.

    Starts with the people exposed to risk factors.

    3

    Involves fewer number of subjects.

    Involves larger number of subjects.

    4

    Quick results

    Delayed results.

    5
    6

    Relatively inexpensive.

    Odd ratio.

    Expensive.
    Incidence rate.




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